Despite this small percentage, when an individual reaches 70 years of age, he has produced more than 900 kg of oxygen radicals. An especially toxic radical is the hydroxyl radical (• OH) because, due to its high reactivity, it indiscriminately attacks all molecules.
Most proteins damaged by free radicals are enzymes nulante, mainly enzymes that contain transition metals, because of their high risk of generating H in the vicinity of the protein. The proteins damaged by oxidation accumulate with age, estimated at 30-50% of the total cellular proteins present in old age.
Thursday, February 7, 2019
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